Efficacy and Safety of Uro-Vaxom Treatment for Patients with Recurrent Cystitis: An Open Multicenter Study.
10.4111/kju.2007.48.4.428
- Author:
Seung Ju LEE
1
;
Su Jin KIM
;
Yong Hyun CHO
;
Young Nam WOO
;
Bup Wan KIM
;
Young Sun KIM
;
Sung Goo CHANG
;
Min Eui KIM
;
Chul Sung KIM
;
Jeong Gu LEE
;
Bong Suck SIM
;
Hyung Jin KIM
;
Byung Ha CHUNG
;
In Rae CHO
;
Sang Don LEE
Author Information
1. Daniel Urology Clinic, Korea.
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Female;
Cystitis;
Escherichia coli;
Uro-Vaxom
- MeSH:
Adult;
Cystitis*;
Dysuria;
Escherichia coli;
Female;
Humans;
Incidence;
Recurrence
- From:Korean Journal of Urology
2007;48(4):428-432
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We wanted to investigate the efficacy and safety of the immunotherapeutic Uro-Vaxom for treating uncomplicated recurrent cystitis in female patients only. MATERIALS AND METHODS: Adult female patients were enrolled in this multicenter, open-label study if they had acute cystitis at the enrollment visit and positive results on urine culture (> or =10(3)CFU/ml). The patients were treated for 3 months with one capsule daily of Uro-Vaxom after antibiotic therapy, and they were observed for another 3 months. The primary efficacy criteria were the cystitis recurrence rates over 6 months, the distribution of cystitis and the proportion of patients with cystitis. RESULTS: A total of 50 patients were evaluated. During the 6-month trial, the number of cystitis recurrences was significantly reduced in comparison with the 6-month pretrial period (on the average 0.64 as compared to 3.0 recurrences, respectively p<0.001). The incidences of frequency, urgency and dysuria remained low until the end of the trial. Uro-Vaxom was well tolerated: side-effects were mentioned by 8% of the 50 patients, and there was no case leading to treatment withdrawal. CONCLUSIONS: Uro-Vaxom significantly reduced the incidence of cystitis during the 6 months of this study, including the 3 months of treatment. These results demonstrate that Uro-Vaxom is a valuable agent for prophylaxis of recurrent cystitis.
