The bone regenerative effect of silk fibroin mixed with platelet-rich fibrin (PRF) in the calvaria defect of rabbit.
10.5125/jkaoms.2010.36.4.250
- Author:
Ji Young SONG
1
;
HaeYong KWEON
;
Kwang Jun KWON
;
Young Wook PARK
;
Seong Gon KIM
Author Information
1. Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung, Korea. epken@chol.com
- Publication Type:Original Article
- Keywords:
Platelet-rich fibrin (PRF);
Silk fibroin;
Bone regeneration
- MeSH:
Animals;
Bone Regeneration;
Fibrin;
Fibroins;
Parietal Bone;
Rabbits;
Silk;
Skull;
Transplants
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2010;36(4):250-254
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
INTRODUCTION: This study evaluated the bone regenerative effect of silk fibroin mixed with platelet-rich fibrin (PRF) of a bone defect in rabbits. MATERIALS AND METHODS: Ten New Zealand white rabbits were used for this study and bilateral round shaped defects were formed in the parietal bone (diameter: 8.0 mm). The silk fibroin mixed with PRF was grafted into the right parietal bone (experimental group). The left side (control group) was grafted only PRF. The animals were sacrificed at 4 weeks and 8 weeks. A micro-computerized tomography (microCT) of each specimen was taken. Subsequently, the specimens were decalcified and stained for histological analysis. RESULTS: The average value of plane film analysis was higher in the experimental group than in the control group at 4 weeks and 8weeks after surgery. However, the difference was not statistically significant.(P>0.05) The tissue mineral density (TMD) in the experimental group at 4 weeks after surgery was significantly higher than the control group.(P<0.05) CONCLUSION: Silk fibroin can be used as a scaffold of PRF for rabbit calvarial defect repair.
