Embolia Cutis Medicamentosa Following Intramuscular Injection of Diclofenac.
- Author:
Jae Wan GO
1
;
Shin Han KIM
;
Byung In RO
;
Hwa Eun OH
;
Han Kyoung CHO
Author Information
1. Department of Dermatology, Kwandong University College of Medicine, Goyang, Korea. dermy@kd.ac.kr
- Publication Type:Case Report
- Keywords:
Diclofenac;
Nicolau syndrome
- MeSH:
Adult;
Amputation;
Buttocks;
Debridement;
Diclofenac;
Erythema;
Exanthema;
Extremities;
Female;
Humans;
Injections, Intramuscular;
Lower Extremity;
Paralysis;
Pigmentation;
Ulcer
- From:Korean Journal of Dermatology
2010;48(9):786-789
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Nicolau syndrome or embolia cutis medicamentosa is a rare complication of a still largely unidentified pathogenesis at the site of intramuscular injections of various drugs. It is characterized by development of an acute, severe pain around the injection site followed by a localized erythema, a reticular rash, a hemorrhagic patch and varying degrees of tissue damage. The disease outcomes vary from atrophic ulcers and pigmentation to lower limb paralysis and limb amputation. We describe a 34-year-old woman with the diagnosis of this syndrome after she received an intramuscular diclofenac-beta-dimethyl-aminoethanol injection to the lateral aspect of the right upper buttock. The patient was treated by surgical debridement with concomitant primary closure.
