Efficacy of High Dose Corticosteroid Therapy in Experimental Traumatic Optic Neuropathy.
- Author:
Sang Yeul LEE
1
;
Sung Joo KIM
;
Hye Young KIM
;
Chang Hoon HAM
;
Kang Won CHO
;
Tai Seung KIM
Author Information
1. Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Corticosteroid therapy;
Optic nerve;
Traumatic optic-neuropathy
- MeSH:
Culicidae;
Dexamethasone;
Optic Nerve;
Optic Nerve Injuries*;
Rabbits
- From:Journal of the Korean Ophthalmological Society
1995;36(12):2213-2217
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We investigated the efficacy of high dose corticosteroid therapy in the treatment of traumatic optic-neuropathy. We experimentally damaged the optic nerves of six white rabbits with a Hartman mosquito. Three of the rabbits were intravenously injected with 0.25mg/kg dexamethasone every six hours for a 48 hour period. The others were used as controls. In both groups, the optic nerves were removed after one month and stained with Hematoxyline-eosin, then examined microscopically. No histological differences were found in either the control or the experimental group.
