Brain Stem Blood Flow During Hypercapnia, Hypocapnia, Hypoxia, and Hemorrhagic Hypotension in Newborn Piglet.
- Author:
Tae Young KIM
1
Author Information
1. Department of Nurosurgery, School of Medicine, Wonkwang University, Iri, Korea.
- Publication Type:Original Article
- Keywords:
Brain stem;
Blood flow;
New-born piglet;
CO2 reactivity;
Hypoxia;
Hypotension
- MeSH:
Anoxia*;
Brain Stem*;
Brain*;
Humans;
Hydrogen;
Hypercapnia*;
Hypocapnia*;
Hypotension*;
Infant, Newborn*
- From:Journal of Korean Neurosurgical Society
1995;24(12):1463-1468
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Changes of brain stem blood flow(BBF) during physiologic stimulation, such as hypoxia, hypo-and hypercapnia, and hemorrhagic hypotension, were studied by hydrogen clearance technique through closed clival window in the brain stem of nerborn piglet. Induction of moderate hypercapnia(PaCO2=65.4+/-2.11mmHg) caused prominent increases in BBF(354+/-39%;p<0.0001). Conversely, in response to moderate hypocapnia(PaCO2=23.9+/-0.64mmHg), a significant decreases in BBF(-30.38+/-3.22%;p<0.0001) was observed. During severe hypoxia(PaO2=3.7+/-1.4mmHg)moderate increases in BBF(161+/-51.4%;p=0.005) occurred. Interestingly, in response to systemic hypotension(Mean Arterial Blood Pressure=34+/-0.7mmHg), a nonsignificant reduction of BBF was recorded(-14+/-10%;p=0.240). These findings suggest that CO2 reactivity of newborn piglet posterior circulation is high;however, hypoxic reactivity is relatively moderate, and BBF is autoregulated during systemic hypotension.
