G-protein beta3 Subunit Gene 825C/T Polymorphism Is Not Associated with Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients.
- Author:
Young Min PARK
1
;
Young Cho CHUNG
;
Seung Hwan LEE
;
Kang Joon LEE
;
Hyun KIM
;
Jung Eun CHOI
;
Seung Gul KANG
;
Min Soo LEE
;
Leen KIM
;
Heon Jeong LEE
Author Information
1. Department of Psychiatry, Inje University College of Medicine, Goyang, Korea.
- Publication Type:Original Article
- Keywords:
Olanzapine;
Weight;
Polymorphism;
Schizophrenia
- MeSH:
Antipsychotic Agents;
Benzodiazepines;
Body Mass Index;
Body Weight Changes;
Compliance;
Gene Frequency;
Genotype;
GTP-Binding Proteins;
Heterotrimeric GTP-Binding Proteins;
Humans;
Schizophrenia;
Weight Gain
- From:Psychiatry Investigation
2009;6(1):39-43
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Weight gain is a possible adverse effect of the use of antipsychotics, and is an important factor for long-term health and treatment compliance. Olanzapine is an atypical antipsychotic known to cause considerable weight gain. A relationship between weight gain and the G protein beta3 subunit gene (GNB3) 825C/T polymorphism has been reported. We therefore examined this possible association in a Korean schizophrenic patient group receiving olanzapine treatment. METHODS: Weight and height measurements were obtained prior to starting olanzapine and measured again after long-term treatment. Genotyping for the 825C/T polymorphism was performed using a PCR-based method. RESULTS: We found that long-term treatment with olanzapine resulted in mean gains in weight and body mass index (BMI) of 5.2 kg and 1.93 kg/m2, respectively. There was a no significant difference in the mean body weight change from baseline to the endpoint after olanzapine treatment between the genotype groups (p=0.796). There were also no significant differences in genotype or allele frequencies between the severe weight-gain (more than 10%) and minimal weight-gain (less than 10%) groups (chi-square=0.037, p=0.98; chi-square=0.020, p=0.89). CONCLUSION: The finding from this study thus does not support a relationship between the GNB3 825C/T polymorphism and weight gain in Korean schizophrenic patients receiving olanzapine treatment.
