Comparison of Serum Beta 2-Microglobulin and 24 hour Urinary Creatinine Clearance as a Prognostic Factor in Multiple Myeloma.
10.3346/jkms.2006.21.4.639
- Author:
Jae Pil YUN
1
;
Cheolwon SUH
;
Eunkyoung LEE
;
Jai Won CHANG
;
Won Seok YANG
;
Jung Sik PARK
;
Su Kil PARK
Author Information
1. Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea. skpark@amc.seoul.kr
- Publication Type:Original Article ; Comparative Study
- Keywords:
Multiple Myeloma;
beta 2-Microglobulin;
Glomerular Filtration Rate
- MeSH:
beta 2-Microglobulin/*blood;
Survival Analysis;
Retrospective Studies;
Prognosis;
Neoplasm Staging/methods;
Multivariate Analysis;
Multiple Myeloma/drug therapy/metabolism/*pathology;
Creatinine/*urine
- From:Journal of Korean Medical Science
2006;21(4):639-644
- CountryRepublic of Korea
- Language:English
-
Abstract:
A new staging system for multiple myeloma (MM) has utilized serum concentrations of beta 2-microglobulin (S beta2 M) and albumin as important prognostic factors for survival. Since S beta2 M is an indicator of glomerular filtration rate, we compared the prognostic values of S beta2 M and 24-hr urinary creatinine clearance (Ccr) in patients with MM. We retrospectively reviewed the records of 170 MM patients from January 1996 to November 2003 whose 24-hr urinary Ccr was available at the time of diagnosis. We found that pretreatment S beta2 M was inversely related to Ccr (Spearman's correlation coefficient=-0.787). In univariate analysis, the hazard ratio (HR) of death was 1.043 (p<0.001) for S beta2 M and 0.985 (p<0.001) for Ccr. Multivariate analysis showed that S beta2 M (HR 1.030, p=0.010) and Ccr (HR 0.993, p=0.059) were significant prognostic factors in patients' survival. In conclusion, 24-hr urinary Ccr may be utilized for staging of patients with MM.
