The Clinical Significance of Serum and Urinary Neopterin Levels in Several Renal Diseases.
10.3346/jkms.2006.21.4.678
- Author:
Hyun Young LHEE
1
;
Hyang KIM
;
Kwan Joong JOO
;
Soo Suk JUNG
;
Kyu Beck LEE
Author Information
1. Department of Internal Medicine, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea. hyang77.kim@samsung.com
- Publication Type:Original Article ; Comparative Study
- Keywords:
Kidney Diseases;
Neopterin;
Nephrotic Syndrome;
Kidney Failure
- MeSH:
Triglycerides/blood;
Radioimmunoassay/methods;
Nephrotic Syndrome/blood/pathology/urine;
Neopterin/*blood/*urine;
Middle Aged;
Male;
Kidney Failure, Chronic/blood/pathology/urine;
Kidney Diseases/blood/*pathology/urine;
Humans;
Hemoglobins/metabolism;
Hematocrit;
Female;
Creatinine/blood;
Blood Urea Nitrogen;
Aged;
Age Factors;
Adult
- From:Journal of Korean Medical Science
2006;21(4):678-682
- CountryRepublic of Korea
- Language:English
-
Abstract:
Neopterin is a pyrazino-pyrimidine compound, and is known to be a marker associated with cell-mediated immunity in various diseases. We hypothesized that the levels of serum and urine neopterin would be elevated in renal disease, and would correlate with certain clinical parameters. We evaluated serum and urinary neopterin levels in patients with several renal diseases, including nephrotic syndrome (NS, n=19), chronic renal failure (CRF, n=8), end stage renal disease (ESRD, n=64) and controls (n=22). Serum neopterin was elevated in patients with CRF and ESRD, as compared to controls. Urinary neopterin levels were also found to be elevated in patients with CRF and ESRD, as compared to controls. Serum neopterin levels showed significant positive correlation with age, serum BUN and creatinine levels, and inverse correlation with WBC, hemoglobin, hematocrit, serum albumin and total iron binding capacity. Urine neopterin levels exhibited positive correlation with age and serum creatinine levels, and inverse correlation with WBC, hemoglobin, hematocrit, BUN and serum albumin. In conclusion, increased serum and urinary neopterin levels were found in some patients with renal disease and were correlated with certain clinical parameters.
