Cutoff Values of Surrogate Measures of Insulin Resistance for Metabolic Syndrome in Korean Non-diabetic Adults.
10.3346/jkms.2006.21.4.695
- Author:
Sihoon LEE
1
;
Sunghee CHOI
;
Hae Jin KIM
;
Yoon Sok CHUNG
;
Kwan Woo LEE
;
Hyun Chul LEE
;
Kap Bum HUH
;
Dae Jung KIM
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Insulin Resistance;
Metabolic Syndrome X
- MeSH:
Triglycerides/blood;
Predictive Value of Tests;
Multivariate Analysis;
Middle Aged;
Metabolic Syndrome X/*blood/diagnosis/physiopathology;
Male;
Korea;
*Insulin Resistance;
Insulin/*blood;
Humans;
Female;
Fasting/blood;
Diabetes Mellitus/blood/physiopathology;
Cholesterol, HDL/blood;
Cholesterol/blood;
Blood Pressure/physiology;
Blood Glucose/analysis;
Aged;
Adult
- From:Journal of Korean Medical Science
2006;21(4):695-700
- CountryRepublic of Korea
- Language:English
-
Abstract:
We investigated the cutoff values of surrogate of insulin resistance for diagnosing metabolic syndrome in Korean adults. The data from 976 non-diabetic individuals (484 men and 492 women) aged 30-79 yr were analyzed. We determined the odds ratios for the prevalence of metabolic syndrome according to the quartiles of fasting insulin, homeostasis model for insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (QUICKI) as independent variables, while adjusting for age, sex, and body mass index. The cutoff values of fasting insulin, HOMA-IR, and QUICKI were estimated by the areas under the receiver-operating characteristic (ROC) curves. The cutoff points for defining insulin resistance are a fasting insulin level of 12.94 micro U/mL, HOMA-IR=3.04 as the 75th percentile value, and QUICKI=0.32 as the 25th percentile value. Compared with the lowest quartile, the adjusted odds ratios for the prevalence of metabolic syndrome in the highest quartiles of fasting insulin, HOMA-IR, and QUICKI were 1.95 (1.26-3.01), 2.27 (1.45-3.56), and 2.27 (1.45-3.56), respectively. The respective cutoff values for fasting serum insulin, HOMA-IR, and QUIC-KI by ROC analysis were 10.57 micro U/mL (sensitivity 58.5%, specificity 66.8%), 2.34 (sensitivity 62.8%, specificity 65.7%), and 0.33 (sensitivity 61.2%, specificity 66.8%). Fasting insulin, HOMA-IR, and QUICKI can be used as surrogate measures of insulin resistance in Korean non-diabetic adults.
