Association Between Suicide Attempts in Patients With Depressive Disorder and Tryptophan Hydroxylase A218C Polymorphism.
- Author:
Se Hoon SHIM
1
;
Bo Young HWANG
;
Young Joon KWON
;
Hee Yeon JUNG
;
Bun Hee LEE
;
Yong Ku KIM
Author Information
1. Department of Psychiatry, College of Medicine, Soonchunhyang University, Cheonan Hospital, Cheonan, Korea.
- Publication Type:Original Article
- Keywords:
Suicide;
Tryptophan hydroxylase (TPH);
Depression;
Association study
- MeSH:
Case-Control Studies;
Depression;
Depressive Disorder;
Diagnostic and Statistical Manual of Mental Disorders;
Emergencies;
Gene Frequency;
Genotype;
Humans;
Introns;
Serotonin;
Suicide;
Suicide, Attempted;
Tryptophan;
Tryptophan Hydroxylase
- From:Journal of Korean Neuropsychiatric Association
2008;47(2):142-152
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Several lines of evidence suggest the serotonergic dysfunction involved in the biological susceptibility of suicide. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, plays a vital role in serotonin metabolism. In a case-control study, we investigated whether the TPH gene was a susceptible factor for suicidal behavior in depressive patients. METHODS: The subjects were 218 depressed patients who attempted suicide and visited emergency rooms in multi-medical centers. One hundred thirty hospitalized non-suicidal depressed patients and the 161 normal controls were matched with the suicidal group. Individuals in all 3 groups were evaluated independently by a Structured Clinical Interview for the purpose of establishing a DSM-IV criteria diagnosis (SCID). The severity of depressive symptoms was evaluated using Hamilton depression rating scale (HDRS). RESULTS: There was no significant difference in genotype distributions and allele frequencies of TPH intron 7 A218C polymorphisms among 3 groups. Furthermore, no significant difference in genotype counts and allele frequencies of the polymorphisms was found among lethal suicidal depressed patients, non-suicidal depressed patients and the normal controls. CONCLUSION: This study suggests that the A218C polymorphism of the TPH gene is unlikely to have a major effect on the susceptibility of suicidal behaviors in depressive patients.
