The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis.
- Author:
Young Ran PARK
1
;
Suck Chei CHOI
;
Soo Teik LEE
;
Kyung Suk KIM
;
Soo Cheon CHAE
;
Hun Taeg CHUNG
Author Information
1. Genome Research Center for Immune Disorders, Wonkwang University School of Medicine, Chonbuk 570-749, Korea. chaesc@wonkwang.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
colitis ulcerative;
inflammatory bowel diseases;
polymorphism, single nucleotide
- MeSH:
Adult;
Alleles;
Asian Continental Ancestry Group/*genetics;
Case-Control Studies;
Chemokines, CC/*genetics;
Colitis, Ulcerative/ethnology/*genetics;
Female;
Genetic Predisposition to Disease/*genetics;
Haplotypes;
Humans;
Korea;
Male;
Middle Aged;
Polymorphism, Genetic/*genetics;
Research Support, Non-U.S. Gov't
- From:Experimental & Molecular Medicine
2005;37(6):553-558
- CountryRepublic of Korea
- Language:English
-
Abstract:
The eotaxin gene family (eotaxin, eotaxin-2 and eotaxin-3) have been implicated in the recruitment of eosinophils, basophiles and helper T (Th) 2 lymphocytes that is a central aspect of allergic disease. We previously suggested that Eo2+179T>C and Eo2 +275C>T of the eotaxin-2, and Eo3 +2497T>G of the eotaxin-3 were significantly associated with susceptibility to asthma. To determine whether the single nucleotide polymorphisms (SNPs) of eotaxin-2 and eotaxin-3 gene family are associated with the susceptibility of ulcerative colitis (UC), we analyzed the genotype of 119 patients with UC and 303 controls using single-base extension (SBE) method. We also calculated the haplotype frequencies among Eo2 +179T>C and Eo2 +275C >T of the eotaxin-2 and Eo3 +2497T>G of the eotaxin-3 in both control and UC patients. The genotype frequency of Eo2 +179T>C and Eo2 +275C>T between UC patients and controls were significantly different (P=0.006 and 0.022, respectively). The genotype and allele frequencies of EoA2497T>G in UC patients were not significantly different from those in the controls without UC patients. Our results suggest that Eo2 +179T>C and Eo2 +275C>T of eotaxin-2 might be associated with the susceptibility of UC.
