The Effect of Continuous Infusion of Ondansetron on Nausea and Vomiting during Intravenous Patient-controlled Analgesia.
10.4097/kjae.2004.47.6.830
- Author:
Kyungil HWANG
1
;
Kyudae SHIM
;
Sangho LEE
;
Hoondo KIM
Author Information
1. Departments of Anesthesiology and Pain Medicine, Wooridul Spine Hospital, Seoul, Korea. usu97@naver.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
IV-PCA;
ondansetron;
postoperative nausea and vomiting (PONV)
- MeSH:
Analgesia, Patient-Controlled*;
Humans;
Incidence;
Nausea*;
Ondansetron*;
Passive Cutaneous Anaphylaxis;
Postoperative Nausea and Vomiting;
Vomiting*
- From:Korean Journal of Anesthesiology
2004;47(6):830-833
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This study was designed to determine the effectiveness of the continuous infusion of ondansetron for the prevention of postoperative nausea and vomiting (PONV) in intravenous patient-controlled analgesia (PCA). METHODS: One hundred and sixty patients undergoing spinal surgery were randomized into four groups according to the method of ondansetron administration, placebo (n = 40, group 1), ondansetron 8 mg mixed to IV PCA (n = 40, group 2), ondansetron 4 mg IV before induction or after surgery in addition to 8 mg mixed to IV PCA (n = 40, group 3 or n = 40, group 4). The incidences of nausea, vomiting, and side effects were recorded for 48 hr postoperatively. RESULTS: The incidence of nausea in group 1 (43 %) was significantly higher than in the other groups (group 2; 18%, group 3; 15%, group 4; 18%) (P < 0.05), and vomiting was one in group 1. CONCLUSIONS: Continuous ondansetron infusion is effective at preventing PONV, but the effects of additional bolus injections to continuous infusion of ondansetron were not different from continuous infusion only.
