Effect of Transdermal Fentanyl Patches on the Motility of the Sphincter of Oddi.
- Author:
Hyun Cheol KOO
1
;
Jong Ho MOON
;
Hyun Jong CHOI
;
Kyoung Hwa HWANG
;
Hyo Jin MAENG
;
Hyung Ki KIM
;
Jong Kyu PARK
;
Su Jin HONG
;
Young Koog CHEON
;
Young Deok CHO
;
Joon Seong LEE
;
Moon Sung LEE
Author Information
1. Digestive Disease Center, Department of Internal Medicine, Soon Chun Hyang University School of Medicine, Bucheon and Seoul, Korea. jhmoon@schbc.ac.kr
- Publication Type:Original Article
- Keywords:
Sphincter of Oddi manometry;
Transdermal fentanyl patch;
Pancreatitis
- MeSH:
Analgesics;
Catheters;
Dependency (Psychology);
Fentanyl;
Humans;
Manometry;
Pancreatitis;
Prospective Studies;
Sphincter of Oddi
- From:Gut and Liver
2010;4(3):368-372
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Pain is one of the most troublesome symptoms of pancreatitis. Transdermal fentanyl patches (TFPs) are long-acting analgesics with a reduced risk of dependency. This prospective study evaluated the effect of TFPs on sphincter of Oddi (SO) motility for the management of pain in pancreatitis. METHODS: SO manometry (SOM) was performed using triple-lumen catheters anterogradely inserted through the percutaneous transhepatic route during cholangioscopy in 16 patients. The basal pressure, amplitude, and frequency of the SO were assessed before and after applying a TFP at 24 hour at doses of 25 and 12.5microgram/hr, respectively. RESULTS: Two of 16 patients receiving a 25microgram/hr. TFP were excluded because of adverse side effects (headache and/or nausea). The mean basal pressure, amplitude, and frequency of SOM did not change significantly in the 25microgram/hr TFP group (n=4 patients). Parameters of SO function also did not significantly change in the 12.5microgram/hr TFP group (n=11 patients). CONCLUSIONS: TFPs below a dose of 25microgram/hr may not affect the motility of the SO. Administration of TFPs at lower dosages seems to be a safe analgesic treatment for the pain control of patients with pancreatitis without affecting the function of the SO.
