A Case of Acute Necrotizing Encephalopathy.
- Author:
Sung Kee KIM
1
;
Se Wook OH
;
Young Kyoun KIM
;
Se Chang HAM
;
Yong Won PARK
;
Sang Woo KIM
Author Information
1. Department of Pediatrics, College of Medicine, Inje University, Seoul Paik Hospital, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Acute encephalopathy
- MeSH:
Arm;
Blood-Brain Barrier;
Brain;
Brain Stem;
Child;
Humans;
Infant;
Japan;
Leg;
Magnetic Resonance Imaging;
Male;
Neurologic Manifestations;
Prognosis;
Seizures;
Taiwan;
Thalamus
- From:Journal of the Korean Pediatric Society
2001;44(8):954-958
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This disease predominantly affects infants and young children living in Japan and Taiwan, and manifests itself as acute encephalopathy following viral infections. The hallmark of this encephalopathy is multifocal, symmetric brain lesions affecting bilateral thalamus, brainstem tegmentum, cerebral periventricular white matter and cerebellar medulla, which can be visualized by computed tomography and magnetic resonance imaging. Both the gray and white matter are involved, with neuropathological evidence of local breakdown of the blood-brain barrier. The prognosis was poor in the 1980s, but has improved recently. A characteristic combination of focal neurologic signs is often recognized as the sequelae. We experienced a case of a 7-month-old male infant who had been transferred to our hospital for comatous mentality and clonic seizure of both arms and legs. We report this case with a review of the related literatures.
