Serum Cystatin C Reflects the Progress of Albuminuria.
10.4093/dmj.2011.35.6.602
- Author:
Jeong Seon YOO
1
;
Young Mi LEE
;
Eun Hae LEE
;
Ji Woon KIM
;
Shin Young LEE
;
Ki Cheon JEONG
;
Shin Ae KANG
;
Jong Suk PARK
;
Joo Young NAM
;
Chul Woo AHN
;
Young Duk SONG
;
Kyung Rae KIM
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. acw@yuhs.ac
- Publication Type:Original Article
- Keywords:
Albuminuria;
Cystatin C;
Creatinine;
Diabetes mellitus, type 2;
Diabetic nephropathies
- MeSH:
Albuminuria;
Creatinine;
Cystatin C;
Diabetes Mellitus, Type 2;
Diabetic Nephropathies;
Diet;
Follow-Up Studies;
Glomerular Filtration Rate;
Humans;
Outpatients;
Retrospective Studies
- From:Diabetes & Metabolism Journal
2011;35(6):602-609
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Research on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate. METHODS: We enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic. RESULTS: With the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR. CONCLUSION: Serum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients.
