Treatment of Unresectable Non-Small-Cell Lung Cancer with Curative Radiotherapy.
- Author:
Il han KIM
1
;
Sung Whan HA
;
Charn Il PARK
;
Young Soo SHIM
;
Noe Kyeong KIM
;
Keun Youl KIM
;
Yong Chol HAN
Author Information
1. Department of Radiology, College of Medicine, Seoul National University, Korea.
- Publication Type:Original Article
- MeSH:
Carcinoma;
Carcinoma, Squamous Cell;
Humans;
Lung Neoplasms*;
Lung*;
Lymph Nodes;
Neoplasm Metastasis;
Radiation Oncology;
Radiotherapy*;
Seoul;
Thorax;
Yemen
- From:Journal of the Korean Society for Therapeutic Radiology
1984;2(2):203-212
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
From 1979 to 1982, 80 patients with unresectable non-mall-ell lung cancer without metastasis were treated with high-ose radiotherapy to the primary and to regional lymph nodes with or without supraclavicular lymphatic in the Department of Therapeutic radiology, Seoul National University Hospital. Of these, 56 patients (70%) were completely evaluable, and 59 patients (74%) had squamous cell carcinoma, 13% large cell undifferentiated carcinoma and 8% Aden carcinoma. 21 patients (26%) had Stage II and 59 patients (74%) had Stage III. The complete and partial response rate in the high-ose (~ 6,000rad) radiotherapy was 70% with 19% complete response. 69 patients (86%) failed in the treatment, by the failure pattern, 64% had local failure alone, 35% had local failure and distant metastasis and 1% had distant metastasis alone. The failure rate in the thorax was 76% in squamous cell carcinoma, 40% in Aden carcinoma and 20% in large cell undifferentiated carcinoma. Preliminary result shows that actuarial survival at 1, 2 and 3 years were 56%, 26% and 20% in overall patients and 64%, 37% and 21% in Stage II and 54%, 21% and 18% in Stage III, respectively. Overall median survival was 14 months; 17 months in Stage II and 13 months in Stage III. 8 patients (10%) have lived a minimum of 2 years with no evidence of disease. There was no fatal complication confirmed to be induced by radiotherapy, so definitive high-ose radiotherapy was tolerated well without major problems and resulted in good local control and survival.
