Granulocyte-Colony Stimulating Factor(G-CSF) Treatment of Clozapine-induced Agranulocytosis.
- Author:
Chuleung KIM
1
;
Sangeun SHIN
Author Information
1. Department of Psychiatry, College of Medicine, Inha University, Incheon, Korea.
- Publication Type:Case Report
- Keywords:
Clozapine;
Agranulocytosis;
G-CSF
- MeSH:
Adult;
Agranulocytosis*;
Clozapine;
Education;
Granulocyte Colony-Stimulating Factor;
Humans;
Incidence;
Knowledge Bases;
Leukocytes;
Male
- From:Korean Journal of Psychopharmacology
1998;9(1):91-97
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
After 31 weeks of treatment with clozapine, severe agranulocytosis was diagnosed in a 35-year-old male schizophrenic patient. The patient was treated sucessfully with a granulocyte colony-stimulating factor (G-CSF). The leukocyte court was 300/mm(3) on admission. After 10 days treatment with G-CSF, the hematological status normalized. Despite its clinical advantages, the use of clozapine has been limited by a propensity to induce agranulocytosis in 1-2% of the patients who are treated with this compound. In addition to case report, authors reviewed the indications for clozapine treatment and the present knowledge base regarding the incidence, monitoring and management of agranulocytosis. Unfortunately, clozapine-induced agranulocytosis cannot be prevented, so regular blood examination and education for patient and family member are very important and early treatment with G-CSF seems warranted in severe cases of clozapine-induced agranulocytosis.
