'Pauci-immune' rapidly progressive glomerulonephritis associated with systemic vasculitis.
10.3346/jkms.1992.7.3.264
- Author:
Ji Youn HAN
1
;
Sun Ae YOON
;
Jea Young WOO
;
In Seok PARK
;
Suk Young KIM
;
Yoon Sik CHANG
;
Byung Kee BANG
Author Information
1. Department of Internal Medicine, Catholic University Medical College, Seoul, Korea.
- Publication Type:Case Reports
- Keywords:
Systemic vasculitis;
rapidly progressive glomerulonephritis
- MeSH:
Adult;
Antibodies, Antineutrophil Cytoplasmic;
Autoantibodies/analysis;
Cyclophosphamide/therapeutic use;
Drug Therapy, Combination;
Female;
Glomerulonephritis/*complications/immunology/pathology/therapy;
Humans;
Kidney/ultrastructure;
Prednisolone/therapeutic use;
Renal Dialysis;
Vasculitis/*complications
- From:Journal of Korean Medical Science
1992;7(3):264-270
- CountryRepublic of Korea
- Language:English
-
Abstract:
'Pauci-immune' glomerulonephritis has been recognized as an important cause of rapidly progressive glomerulonephritis. The paucity of immune deposits can be separated from the other two major immunohistologic variants of crescentic glomerulonephritis, ie, antiglomerular basement membrane (GBM) antibody-mediated and immune complex-mediated glomerulonephritis. Here we describe the case of a 42-year-old woman with pauci-immune' glomerulonephritis and vasculitis presenting as rapidly progressive renal failure with characteristic pathologic and immunohistologic findings. And in this case, despite oliguria and rapid deterioration of renal function, the renal function recovered partially and continued to be stabilized with a favourable response to hemodialysis and combined system immunosuppressive therapy.
