Relationship of anemia and uric acid with clinical outcomes in congestive heart failure.
- Author:
Chang Hee HAN
1
;
Young Keun ON
;
John SUH
;
Do Hwoi KIM
;
Duk Won BANG
;
Min Su HYON
;
Sung Koo KIM
;
Young Joo KWON
Author Information
1. Department of Internal Medicine, Soonchunhyang University Medical College Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Uric acid;
Anemia;
Heart failure
- MeSH:
Anemia*;
Estrogens, Conjugated (USP)*;
Follow-Up Studies;
Heart Failure*;
Hematocrit;
Humans;
Male;
Mortality;
Uric Acid*
- From:Korean Journal of Medicine
2005;68(6):638-646
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Serum uric acid (UA) and anemia could be a valid and useful prognostic marker of chronic heart failure (CHF). We investigated the relationship of anemia and UA with clinical outcomes in CHF patients. METHODS: We analyzed 109 patients with congestive heart failure between August 2001 and October 2002 (age 67 +/- 15 years, follow-up 14 +/- 5 months). We distributed the patients into 3 groups according to hematocrit (Hct) level [Hct group 1 (Hct <30%, n=21), Hct group 2 (Hct 30~38%, n=49), Hct group 3 (Hct >38%, n=39)] and into 3 groups according to serum uric acid (UA) level [UA group I (UA <5.2 mg/dL, n=20), UA group II (UA 5.2~7.5 mg/dL, n=25), UA group III (UA >7.5 mg/dL, n=20)]. Primary end point were rehospitalization resulting from aggravation of CHF and all-cause of death. RESULTS: Among the groups according to Hct level, readmission rates were 57.1%, 28.6%, 15.4%, respectively (p<0.05). Among men, readmission rates were 82.3%, 22.2%, 14.3%, respectively (p<0.05). No significant difference in death rate was observed among the 3 groups. Among the groups according to UA level, there was no significant difference in readmission rates. Death rates were 5%, 8%, 35%, respectively (p<0.05) and there was significant difference in death rate especially among male patients. CONCLUSION: In male patients, lower hematocrit level was associated with higher readmission rate and higher serum uric acid level was associated with death rate.
