Pregnancy Outcomes after Peri-conceptional Medication Exposure; 10 Years Experience: Study for Application of Reproductive Toxicity Information.
- Author:
June Seek CHOI
1
;
Jung Yeol HAN
;
Hyun Kyong AHN
;
Si Won LEE
;
Min Hyoung KIM
;
Jin Hoon CHUNG
;
Hyun Mee RYU
;
Moon Young KIM
;
Jae Hyug YANG
;
Kyu Hong CHOI
;
Ho Won HAN
;
Shin Hye KIM
;
Mi Bum LEE
;
You Jung HAN
;
Noh Mi CHOI
;
Yeon Kyung CHO
;
So Young LEE
;
Dal Soo HONG
;
Ok Ryong LIM
;
Soon Cheol HONG
Author Information
1. The Korean Motherisk Program, Seoul, Korea. hanjungyeol@yahoo.com
- Publication Type:Original Article
- Keywords:
Pregnancy;
Dvelopmental and reproductive toxicity;
Teratogen;
Drug exposure during pregnancy
- MeSH:
Acetaminophen;
Chlorpheniramine;
Chronic Disease;
Congenital Abnormalities;
Counseling;
Female;
Fetal Death;
Humans;
Infant, Low Birth Weight;
Infant, Newborn;
Korea;
Maleates;
Parturition;
Pregnancy;
Pregnancy Outcome;
Pregnant Women;
Premature Birth;
Pseudoephedrine;
Risk Assessment
- From:Korean Journal of Perinatology
2010;21(1):48-58
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In Korea, pregnancy termination is frequently reported among women who took medications for an acute or chronic disease during pregnancy, for fear of teratogenic risk. We have previously shown that a service providing evidence-based information is helpful for women who week counseling to make a rational decision regarding their pregnancies. This study aimed to evaluate whether termination of pregnancy based on such perceptions, is justified using the 'DRug Exposure and risk Assessment in Moms' (DREAM) registry. METHODS: The study included 5,032 consenting pregnant women from the clinic and call center at the Korean Motherisk Program, from November 1999 to October 2008. The DREAM registry recorded the pregnancy outcomes (preterm birth, low birth weight, intrauterine fetal death, and congenital anomaly) of 3,328 women. RESULTS: Among women exposed to medications, time of exposure ranged from 3.5-4.6 weeks of gestation. There were 1,308 different drugs prescribed to these women. The drug most frequently prescribed was acetaminophen followed by chlorpheniramine maleate, and pseudoephedrine. There were 4.7% (n=156/3,328) women who underwent a voluntary abortion for fear of birth defects. We compared frequency of birth defects between exposed women and unexposed pregnant women in our institution during gestation. The frequency of major congenital malformations was 2.5% (n=74/2,977) in exposed group and 2.9% (n=75/2,573) in unexposed group (P=0.32). There was no statistically significant difference between exposed and control group in the rate of preterm births, intrauterine fetal death and low-birth weight babies. CONCLUSION: We did not observe increased risk of congenital malformations and adverse pregnancy outcomes in a population of pregnant women exposed to a variety of medications. Therefore these medications are not considered teratogen.
