A case of hypokalemic perodic paralysis induced by hyperinsulinemia.
- Author:
Jin Hyuck CHANG
1
;
Chul Sik KIM
;
Jong Kwan PARK
;
Jina PARK
;
Min Ho CHO
;
Chul Woo AHN
;
Kyung Rae KIM
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. acw@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Paralysis;
Hypokalemic Periodic;
Hyperinsulinemia
- MeSH:
Adult;
Aldosterone;
Blood Glucose;
Extremities;
Glucose;
Glucose Tolerance Test;
Humans;
Hydrocortisone;
Hyperinsulinism*;
Hypokalemia;
Hypokalemic Periodic Paralysis;
Insulin;
Muscle Weakness;
Paralysis*;
Potassium;
Potassium Channels, Inwardly Rectifying;
Renin;
Thyroid Gland
- From:Korean Journal of Medicine
2005;68(6):692-696
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hypokalemia periodic paralysis, a clinical syndrome characterised by systemic weakness and low serum potassium, is a rare but treatable cause of acute weakness. Attacks of flaccid paralysis can be associated with hypokalemia triggered by insulin. Insulin reduce the conductance of the inward rectifier K+ channel for outward-flowing currents. Therefore, insulin potentiates depolarization of hypokalmeic periodic paralysis. We have experienced a case of hypokalemic periodic paralysis induced by hyperinsulinemia in 38-year old man, with complaint of intermittent paralysis of extremities. On admission, serum K+ was 2.1 mEq/L. He was no family history of muscle weakness. Thyroid function was normal. Serum levels of aldosterone, renin and cortisol were normal. Random plasma glucose level was 129 mg/dL and serum insulin was 131 uIU/mL. Shortly after intravenous supplementation of potassium, muscle weakness was improved. Oral glucose tolerance test revealed impaired glucose tolerance and hyperresponse of insulin and phosphate.
