Effects of Polydeoxyribonucleotide in the Treatment of Pressure Ulcers.
10.3346/jkms.2014.29.S3.S222
- Author:
Jung Yoon KIM
1
;
Chang Sik PAK
;
Ji Hoon PARK
;
Jae Hoon JEONG
;
Chan Yeong HEO
Author Information
1. Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Korea. lionheo@snu.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Pressure Ulcers;
Polydeoxyribonucleotides;
Re-epithelialization
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Female;
Humans;
Injections, Intramuscular;
Male;
Middle Aged;
Polydeoxyribonucleotides/*therapeutic use;
Pressure Ulcer/*drug therapy;
Treatment Outcome;
Wound Healing/*drug effects;
Young Adult
- From:Journal of Korean Medical Science
2014;29(Suppl 3):S222-S227
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study aimed to examine the positive effects of polydeoxyribonucleotide (PDRN) on the wound-healing process in pressure ulcers. In this randomized controlled trial, the effects of PDRN were compared over time between an experimental group (n=11) and a control group (n=12). The former was administered the same dose of PDRN intramuscularly (1 ampule, 3 mL, 5.625 mg, for 5 days) for 2 weeks and perilesionally (1 ampule, 3 mL, 5.625 mg, twice a week) for 4 weeks. The primary endpoint for determining efficacy was wound healing in the pressure ulcers, which was reflected by the wound surface area determined using VISITRAK Digital (Smith & Nephew, Largo, FL). The secondary endpoint was the pressure ulcer scale for healing score, determined using pressure ulcer scale for healing (PUSH Tool 3.0 developed by the National Pressure Ulcer Advisory Panel). After the 4-week treatment period, PDRN therapy was found to significantly reduce the wound size and PUSH score, without adverse effect during the treatment. The findings indicate that PDRN can positively modify the wound healing process in pressure ulcers, and its use could improve the clinical outcomes of patients and lower the need for additional therapies or hospital stay.
