Klinefelter's syndrome: 16 cases.
- Author:
Jong Kwon KIM
1
;
Dong Han KIM
Author Information
1. Department of Urology, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Klinefelter's syndrome
- MeSH:
Azoospermia;
Basement Membrane;
Biopsy;
Congenital Abnormalities;
Cryptorchidism;
Erectile Dysfunction;
Gynecomastia;
Humans;
Hyalin;
Hyperplasia;
Infertility;
Klinefelter Syndrome*;
Male;
Mastectomy;
Orchiectomy;
Plasma;
Semen Analysis;
Seminiferous Tubules;
Testis;
Testosterone
- From:Korean Journal of Urology
1991;32(2):319-323
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Klinefelter's syndrome is found very often among patients whose chief complaint is sterility or genital deformity. In order to discover the clinical manifestations of Klinefelter's syndrome as well as the proper treatment for it, we made some clinical observations. A total of 19 cases were found to have 47, XXY, a typical chromosomal pattern of Klinefelter's syndrome. Observation was made on the 16 cases whose clinical observation was possible. The patients' average age was 26, and their chief complaints were sterility, small testis, gynecomastia, impotence, and cryptorchidism. The testicular volume was under 5ml for all 16 cases. Nine patients who married were sterile and 6 were gynecomastia. The results of semen analysis showed azoospermia in all cases. The biopsy for the patient with cryptorchidism revealed hyalinized seminiferous tubules, thickened basement membrane, and hyperplasia of the interstitial cells. On the hormonal study, plasma FSH was 28.8-80.4 mIU/ ml (N:1-15 mIU /ml) and plasma LH was 18.1-152 mIU/ml (N:1-15 mIU/ml). The plasma testosterone was 0.7-3.8 ng/ml (N:3-10 ng/ml). Treatment was hormonal therapy with testosterone. For two patients who showed gynecomastia, mastectomy was performed. Orchiectomy was performed for one patient with cryptorchidism.
