Detection of human papillomavirus DNA in genital warts showing atypical manifestations.
- Author:
Jee Ho CHOI
;
Kyung Jeh SUNG
;
Mi Woo LEE
;
Jai Kyoung KOH
;
Hee Joon YU
;
Seung Chul LEE
;
Kyoung Chan PARK
- Publication Type:Original Article
- Keywords:
Atypical genital warts;
HPV;
In situ hybridization
- MeSH:
Carcinoma, Squamous Cell;
Condylomata Acuminata*;
DNA*;
Humans*;
In Situ Hybridization
- From:Korean Journal of Dermatology
1991;29(3):377-383
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In situ hybridization using radioactively labeled(S) and nonradioactively labeled probes was performed to detect HPV DNA and to compare the sensitivity of two probes in 17 patients with genital warts showing atypical manifestations. HPV 6/ll was found in 100%(3/3) of the flat type, 50%(2/4) of the pigmented type and 66.7%(2/3) of the flat and pigmented type (except bowenoid papulosis) and 66.7%(2/3) of the large extensive type. However HPV 16/18 was not found at all. In bowenaid papulosis, HPV 16/18 was detected in 25% (1/4) of the cases but HPV 6/11 was negative in all cases. There was no significant difference between the sensitivity of radioactiue and nonradioactive probes. HPV 6/11 was positive in the giant condyloma acuminata complicated with squamous cell carcinoma.
