Clinical Characteristics of Patients with Chronic Kidney Disease Associated with Marked Bradycardia.
- Author:
Doo Hwan CHOI
1
;
Seon Ho AHN
;
Sung Won JUNG
;
Yu Min LEE
;
Hyun Jung KIM
;
Myeung Su LEE
;
Seung Hoon BAEK
;
Ju Hung SONG
Author Information
1. Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea. ashneph@wmc.wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
Bradycardia;
Chronic kidney disease;
Diabetic mellitus;
Hyperkalemia
- MeSH:
Arrhythmias, Cardiac;
Bradycardia*;
Diabetes Mellitus;
Digoxin;
Diltiazem;
Electrocardiography;
Humans;
Hyperkalemia;
Plasma;
Potassium;
Renal Insufficiency, Chronic*
- From:Korean Journal of Nephrology
2004;23(2):256-262
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Since profound hyperkalemia induces fatal arrhythmias, the recognition of its electrocardiographic manifestations is very important. The changes on the ECG correlated roughly with the severity of hyperkalemia. It has been, however, less recognized that severe hyperkalemia is associated with bradycardia. We present 14 patients with chronic kidney disease manifesting marked bradycardia in the presence or absence of hyperkalemia. It is interesting that diabetes mellitus which was complicated in 10 of 14 patients in the present study might exaggerate bradycardia with or without hyperkalemia. 9 patients, who were taking drugs such as diltiazem, beta-blocker, alpha, beta-blocker, and digoxin, developed bradycardia even when their plasma potassium concentration were moderate (<6.5 mEq/L). Therefore, we suggest that synergistic action of these drugs, hyperkalemia, diabetes mellitus, and uremic toxin in patient with chronic kidney disease might play a role in inducing bradycardia.
