Therapeutic Effect of Intra-lesional Triamcinolone Injection on Idiopathic Onychodystrophy.
- Author:
Min Suk LEE
1
;
Mi Yeon KIM
;
Hoon KANG
;
Sang Hyun CHO
;
Young Min PARK
;
Hyung Ok KIM
;
Baik Kee CHO
Author Information
1. Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. yymmpark@hotmail.com
- Publication Type:Original Article
- Keywords:
Idiopathic onychodystrophy;
Intra-lesional triamcinolone injection
- MeSH:
Classification;
Humans;
Onycholysis;
Triamcinolone Acetonide;
Triamcinolone*
- From:Korean Journal of Dermatology
2005;43(6):743-748
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Intra-lesional triamcinolone injection is a widely used treatment modality of onychodystrophy. However, clinical evaluation has rarely been performed for the therapeutic effect of intra-lesional triamcinolone injection in the treatment of idiopathic onychodystrophy, except for psoriatic nail. OBJECTIVE: The purpose of this study was to investigate the therapeutic effect of intra-lesional triamcinolone injection on idiopathic onychodystrophy. METHODS: A total of 43 patients diagnosed as idiopathic onychodystrophy were enrolled in this study. At first 2 visits, triamcinolone acetonide (2.5mg/ml) was injected into the proximal nail fold of each nail using the dermo-jet. Thereafter, intra-lesional injection was performed at 4-week intervals with two-fold increased concentration of triamcinolone acetonide (5mg/ml). After a total of 7 treatments, the treated nails were scored by both doctor and patient between 0 and 10 according to the severity. RESULTS: In 26 patients treated for more than 12-weeks, 189 nails were eventually assessed by four grade scale. Therapeutic effects were as follows; excellent improvement in 19.8%, good in 28.8%, moderate in 11.6%, and poor in 38.6%. Onycholysis responded well to this treatment, with 81.1% of good to excellent improvement, whereas trachyonychia was resistent with 78.1% of poor to moderate improvement. There was no significant side effect, except pain on the injection site. CONCLUSION: According to our results, intra-lesional injection of triamcinolone acetonide is an effective and safe treatment modality of idiopathic onychodystrophy. It is suggested that, with intra-lesional triamcinolone injection, the morphologic classification is an important prognostic factor in the treatment of idiopathic onychodystrophy.
