CDX1 and CDX2 Expression in Intestinal Metaplasia, Dysplasia and Gastric Cancer.
10.3346/jkms.2011.26.5.647
- Author:
Jung Mook KANG
1
;
Byoung Hwan LEE
;
Nayoung KIM
;
Hye Seung LEE
;
Hee Eun LEE
;
Ji Hyun PARK
;
Joo Sung KIM
;
Hyun Chae JUNG
;
In Sung SONG
Author Information
1. Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
CDX1;
CDX2;
Intestinal Metaplasia;
Stomach Neoplasms;
Dysplasia
- MeSH:
Aged;
Female;
Helicobacter Infections/complications/microbiology;
Helicobacter pylori/isolation & purification;
Homeodomain Proteins/*genetics/metabolism;
Humans;
Intestinal Diseases/*genetics/microbiology/pathology;
Male;
Metaplasia/pathology;
Middle Aged;
Polymerase Chain Reaction;
Precancerous Conditions/metabolism/pathology;
Stomach Neoplasms/etiology/*genetics/microbiology
- From:Journal of Korean Medical Science
2011;26(5):647-653
- CountryRepublic of Korea
- Language:English
-
Abstract:
Intestinal metaplasia (IM) has been regarded as a premalignant condition. However, the pathogenesis of IM is not fully understood. The aim of this study was to evaluate the role of CDX1 and CDX2 in the formation of IM and the progression to dysplasia and gastric cancer (GC). A total of 270 subjects included 90 with GC, dysplasia and age- and sex-matched controls. Real-time PCR (RT-PCR) was performed with body specimens for CDX1 and CDX2. The expression of CDX2 was significantly higher in H. pylori positive group than H. pylori negative group (P = 0.045). CDX1 and CDX2 expression increased proportional to the IM grade of the body (P < 0.001). CDX2 expression was significantly higher in incomplete type of IM than in complete type (P = 0.045). The expression of CDX1 in dysplasia group was significantly higher than in the control group (P = 0.001); in addition, CDX1 and CDX2 in cancer group was significantly higher than control group (P < 0.001, and P < 0.001, respectively). Aberrant expression of CDX1 and CDX2 correlated with H. pylori infection and grade of IM in the body. Furthermore, the results suggest that CDX1 and CDX2 play a role in the progression to GC and dysplasia.
