Asymmetry of Dopamine D2/3 Receptor Availability in Dorsal Putamen and Body Mass Index in Non-obese Healthy Males.
- Author:
Sang Soo CHO
1
;
Eun Jin YOON
;
Sang Eun KIM
Author Information
- Publication Type:Original Article
- Keywords: Dopamine; striatum; body mass index; asymmetry
- MeSH: Body Mass Index*; Body Weight; Dopamine*; Eating; Humans; Male; Positron-Emission Tomography; Putamen*
- From:Experimental Neurobiology 2015;24(1):90-94
- CountryRepublic of Korea
- Language:English
- Abstract: The dopaminergic system is involved in the regulation of food intake, which is crucial for the maintenance of body weight. We examined the relationship between striatal dopamine (DA) D2/3 receptor availability and body mass index (BMI) in 25 non-obese healthy male subjects using [11C]raclopride and positron emission tomography. None of [11C]raclopride binding potential (BP) values (measures of DA D2/3 receptor availability) in striatal subregions (dorsal caudate, dorsal putamen, and ventral striatum) in the left and right hemispheres was significantly correlated with BMI. However, there was a positive correlation between the right-left asymmetry index of [11C]raclopride BP in the dorsal putamen and BMI (r=0.43, p<0.05), suggesting that greater BMI is linked with higher receptor availability in the right dorsal putamen relative to the left in non-obese individuals. The present results, combined with previous findings, may also suggest neurochemical mechanisms underlying the regulation of food intake in non-obese individuals.
