Alcohol Consumption as Risk Factor for Progression from Mild Cognitive Impairment to Dementia : A Clinical Research Center for Dementia of South Korea Study.
- Author:
Jinyoung KIM
1
;
Sangha KIM
;
Woojae MYUNG
;
Hyo Shin KANG
;
Duk L NA
;
Seong Yoon KIM
;
Jae Hong LEE
;
Seol Heui HAN
;
Seong Hye CHOI
;
Sang Yun KIM
;
Doh Kwan KIM
Author Information
1. Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. paulkim@skku.edu
- Publication Type:Original Article
- Keywords:
Alzheimer disease;
Alcohol;
Mild cognitive impairment
- MeSH:
Alcohol Drinking*;
Alzheimer Disease;
Cohort Studies;
Dementia*;
Follow-Up Studies;
Humans;
Korea;
Mild Cognitive Impairment*;
Prospective Studies;
Risk Factors*
- From:Journal of Korean Geriatric Psychiatry
2014;18(2):69-75
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Patients with mild cognitive impairment (MCI) are at high risk for dementia. Excessive alcohol consumption is known to adversely affect cognitive function. This study aimed to investigate the relationship between alcohol consumption and the risk for dementia in a cohort of MCI patients. METHODS: Participants (n=416) with (MCI) who met Petersen's criteria were recruited from a nationwide, prospective cohort study of dementia and were followed for a median of 17.52 months (range 5.4-63.48). Alcohol consumption was evaluated at baseline. RESULTS: One hundred twenty seven individuals (30.5%) developed incident dementia (115 Alzheimer disease) during follow-up. Patients with current alcohol consumption at baseline had a higher rate of progression to Alzheimer's dementia than those without current alcohol consumption (hazard ratio 1.61 ; 95% confidence interval 1.03 to 2.53). CONCLUSION: Alcohol consumption may increase the risk of progression to Alzheimer's dementia in patients with MCI.
