Inclusion Body Myositis Distal Myopathy?.
- Author:
Sung Min KIM
1
;
Hyeon Mi LEE
;
Hong Ki SONG
;
Sang Yoon KIM
;
Ki Han KWON
;
Byung Chul LEE
;
Chang Won HA
;
Je Geun CHI
Author Information
1. Department of Neurology, College of Medicine, Hallym University, Korea.
- Publication Type:Case Report
- MeSH:
Cytoplasm;
Diagnosis;
Distal Myopathies;
Female;
Humans;
Inclusion Bodies*;
Lower Extremity;
Male;
Muscle Weakness;
Muscular Diseases*;
Myositis;
Myositis, Inclusion Body*;
Vacuoles
- From:Journal of the Korean Neurological Association
1993;11(3):427-433
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Inclusion body myositis (IBM) is a chronic inflammatory myopathy with characteristic rimmed vacuoles. Cytoplasmic and intranuclear filamentous inclusions in muscle speci men. The clinical features manifest male dominance with the onset between the second and eighth decade but usually after the age of 50 years. Slow progression of painless muscle weakness, normal or mildly elevated serum CK level, myopathic and neurogenic eIectromyographic patterns and refractory to steriod therapy. The presence of rimmed vacuoles and filamentous inclusions in myofiber gives an important clue in the diagnosis of IBM, however, it is very difficult to differentiated young age onset IBM with distally predominant muscle weakness from distal myopathy with rimmed vacuole formation. While we present a young female patient who had slow progression of painless distal muscle weakness in both upper and lower extremities for 1 year, previously published articles concerning of IBM and distal myopathy with rimmed vacuole formation are reviewed and our own differential points are discussed in the diagnosis of this case as IBM.
