A Case of Immune Hemolytic Anemia after Renal Transplantation.
- Author:
Yong Ho CHOI
1
;
Ho Yun CHUNG
;
Hyeon Ok PARK
;
Joo Hyun PARK
;
Hye Soo KIM
;
Jong Min LEE
;
Yong Soo KIM
;
Suk Young KIM
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
- Publication Type:Case Report
- Keywords:
Immune hemolytic anemia;
Kidney transplantation
- MeSH:
Anemia, Hemolytic*;
Antibodies;
Coombs Test;
Cyclosporine;
Humans;
Immunoglobulin G;
Immunosuppression;
Kidney Transplantation*;
Lymphocytes;
Middle Aged;
Prednisolone;
Reticulocyte Count;
Tissue Donors
- From:The Journal of the Korean Society for Transplantation
2000;14(1):109-114
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Several cases of immune hemolytic anemia have been reported after renal transplantation of ABO-minor-mismatch. We present a case of anti-B immune hemolytic anemia which developed on 11th day after renal transplantation. 48-year-old man, blood group Rh(+) AB, had a successful renal transplantation from his distant family, blood group Rh(+) A. He was maintained under immunosuppression with cyclosporine and prednisolone. On 11th day after renal transplantation he had a hemolytic episode. His hemoglobin dropped from 9.2 g/dl to 7.3 g/dl and corrected reticulocyte count increased to 3.7%. The peripheral blood morphology showed polychromatophilia, spherocytosis, and anisocytosis. Direct antiglobulin tests were positive with anti-IgG and anti-C3d. The antibody that caused hemolytic anemia was confirmed as anti-B IgG. The anti-B antibodies might be originated from passenger's donor B lymphocyte.
