A Case of Diffuse Leukoencephalopathy Caused by 5-Fluorouracil Derivatives.
- Author:
Sung Sang YEUN
1
;
Dae Il JANG
;
Kyung Chun JUNG
Author Information
1. Department of Neurology, College of Medicine, Kyunghee University, Korea.
- Publication Type:Brief Communication
- MeSH:
Brain Neoplasms;
Cerebrospinal Fluid;
Distal Myopathies;
Dysarthria;
Dyskinesias;
Female;
Fluorouracil*;
Humans;
Leukoencephalopathies*;
Magnetic Resonance Imaging;
Muscle Weakness;
Stomach Neoplasms;
Vacuoles
- From:Journal of the Korean Neurological Association
1993;11(3):471-473
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A stomach cancer patient is reported, who presented with asterixis and dysarthria, after the administration of 5-fluorouracil derivatives, and progressed to a state of arnnesia and disorientation. At first impression was metastatic brain tumor however7 the result of a cerebrospinal fluid cytology for malignancy was negative, and magnetic resonance imaging study(MRI) revealed diffuse hyperintense lesion of the white matter, indicative of leukoencephalopathy. Upon discontinuing the drugs, patient recovered significantly.lly predominant muscle weakness from distal myopathy with rimmed vacuole formation While we present a young female.
