Intravitreal versus Posterior Subtenon Injection of Triamcinolone Acetonide for Diabetic Macular Edema.
10.3341/kjo.2006.20.4.205
- Author:
Young Jae CHOI
1
;
In Kyung OH
;
Jae Ryung OH
;
Kuhl HUH
Author Information
1. Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea. ojr4991@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Diffuse diabetic macular edema;
Intravitreal injection;
Posterior subtenon injection;
Triamcinolone acetonide
- MeSH:
Vitreous Body;
Visual Acuity;
Triamcinolone Acetonide/*administration & dosage/therapeutic use;
Treatment Outcome;
Tomography, Optical Coherence;
Prospective Studies;
Orbit;
Middle Aged;
Male;
Macular Edema, Cystoid/*drug therapy/etiology/pathology;
Injections;
Humans;
Glucocorticoids/*administration & dosage/therapeutic use;
Fundus Oculi;
Follow-Up Studies;
Fluorescein Angiography;
Female;
Diabetic Retinopathy/*complications/pathology;
Aged
- From:Korean Journal of Ophthalmology
2006;20(4):205-209
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To compare the short-term effects of intravitreal versus posterior subtenon injection of triamcinolone acetonide for diabetic macular edema. METHODS: This is a prospective and interventional study. Sixty eyes of 60 patients who had diffuse diabetic macular edema were assigned to receive a single intravitreal injection (4 mg) or a single posterior subtenon injection (40 mg) of triamcinolone acetonide. The central retinal thickness was measured using optical coherent tomography before injection and at 1 and 3 months after injection. Visual acuity and intraocular pressure (IOP) were also measured. RESULTS: Both intravitreal and posterior subtenon injections of triamcinolone acetonide resulted in significant improvements in visual acuity at 1 month and 3 months after injection. Both groups resulted in a significant decrease in central macular thickness (CMT) at 1 month and 3 months post-injection. IOP in the intravitreal injection group was significantly higher than in the posterior subtenon injection group at 3 months after injection. CONCLUSIONS: The posterior subtenon injection of triamcinolone acetonide had a comparable effect to the intravitreal triamcinolone injection and showed a lower risk of elevated IOP. Posterior subtenon injection of triamcinolone acetonide may be a good alternative for the treatment of diffuse diabetic macular edema.
