Effectiveness of preemptive Gabapentin on postoperative pain after vaginal hysterectomy.
- Author:
Hyun Mi KIM
1
;
Eun Ok KIM
;
Ji Eun SONG
;
Sung Ho PARK
;
Hyun Ah JUN
;
Hongbae KIM
;
Keun Young LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Hallym University, Seoul, Korea. drhbkim@hallym.or.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Gabapentin;
Opioid-sparing;
Postoperative pain
- MeSH:
Amines;
Analgesia, Patient-Controlled;
Antiemetics;
Cyclohexanecarboxylic Acids;
Female;
Fentanyl;
gamma-Aminobutyric Acid;
Humans;
Hysterectomy;
Hysterectomy, Vaginal;
Pain, Postoperative;
Passive Cutaneous Anaphylaxis;
Premedication;
Vomiting
- From:Korean Journal of Obstetrics and Gynecology
2008;51(3):305-312
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Gabapentin is a new generation anticonvulsant drug. Preemptive gabapentin may produce analgesic effect in postoperative patient and have antiemetic effect. The aim of the present study was to investigate the opioid-sparing and analgesic effect of preemptive gabapentin on postoperative pain in patient undergoing vaginal hysterectomy. METHODS: In a randomized, double-blind, controlled study, 40 patients scheduled for an elective vaginal total hysterectomy were investigated/-. The patients were randomized to receive either oral gabapentin 1200mg (GABA group 2, n=17) or 900mg (GABA group 1, n=13) with premedication the night before and again 2hours before surgery. The other group (control group, n=10) had only routine premedication without gabapentin. All patients received patient-controlled analgesia (PCA). Postoperatively, pain was assessed using a visual analogue scale (VAS, 0-10) at time 1, 2, 4, 8, and 20 hours. Cumulative PCA consumption and opioid-related adverse events (nausea, vomiting, dizziness) was recorded. RESULTS: There was significant decrease of fentanly consumption in gabapentin group (GABA 2 group : 57.51+/-8.95 mg, GABA 1 group : 52.21+/-5.78 mg) compared to control group (50.63+/-2.55 mg)(p<0.05). There was no significant difference in side-effect (nausea, vomiting, dizziness) were observed between case and control group. CONCLUSIONS: Preemptive gabapentin has a good analgesic effect and reduce postoperative fentanyl consumption on postoperative pain after vaginal hysterectomy. Gabapentin effectively rescue analgesic requirement in post-operative patients with vaginal total hysterectomy.
