Influence of the Flushing Response in the Relationship between Alcohol Consumption and Cardiovascular Disease Risk.
10.4082/kjfm.2014.35.6.295
- Author:
Hae Sun SUH
1
;
Jong Sung KIM
;
Sung Soo KIM
;
Jin Gyu JUNG
;
Seok Jun YOON
;
Jae Bum AHN
Author Information
1. Department of Family Medicine, Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon, Korea. josephkim@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
Alcohol;
Flushing;
Cardiovascular Diseases;
Risk
- MeSH:
Alcohol Drinking*;
Body Mass Index;
Cardiovascular Diseases*;
Cholesterol;
Chungcheongnam-do;
Drinking;
Flushing*;
Health Promotion;
Heart;
Humans;
Hypotension;
Lipoproteins;
Logistic Models;
Male;
Odds Ratio;
Surveys and Questionnaires;
Triglycerides
- From:Korean Journal of Family Medicine
2014;35(6):295-302
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The purpose of this study was to examine the relationship between cardiovascular disease risk and alcohol consumption according to facial flushing after drinking among Korean men. METHODS: The subjects were 1,817 Korean men (non-drinker group, 283 men; drinking-related facial flushing group, 662 men; non-flushing group, 872 men) >30 years who had undergone comprehensive health examinations at the health promotion center of a Chungnam National University Hospital between 2007 and 2009. Alcohol consumption and alcohol-related facial flushing were assessed through a questionnaire. Cardiovascular disease risk was investigated based on the 2008 Framingham Heart Study. With the non-drinker group as reference, logistic regression was used to analyze the relationship between weekly alcohol intake and cardiovascular disease risk within 10 years for the flushing and non-flushing groups, with adjustment for confounding factors such as body mass index, diastolic blood pressure, low density lipoprotein cholesterol, triglycerides, and exercise patterns. RESULTS: Individuals in the non-flushing group with alcohol consumption of < or =4 standard drinks (1 standard drink = 14 g of alcohol) per week had significantly lower moderate or high cardiovascular disease risk than individuals in the nondrinker group (adjusted odds ratio, 0.51; 95% confidence interval, 0.37 to 0.71). However, no significant relationship between the drinking amount and cardiovascular disease risk was observed in the flushing group. CONCLUSION: Cardiovascular disease risk is likely lowered by alcohol consumption among non-flushers, and the relationship between the drinking amount and cardiovascular disease risk may differ according to facial flushing after drinking, representing an individual's vulnerability.
