Natural Killer Cell Activity in Rheumatoid Arthritis Measured by a Single Cell Cytotoxicity Assay.
10.3349/ymj.1988.29.2.160
- Author:
Gye Sung KIM
1
;
Jung Koo YOUN
;
Joo Deuk KIM
;
Nam Hyun KIM
Author Information
1. Department of Microbiology, Orthopedic Surgery, Yonsei University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Comparative Study ; In Vitro ; Research Support, Non-U.S. Gov't
- Keywords:
Rheumatoid arthritis;
NK cells;
single cell cytotoxicity
- MeSH:
Adolescent;
Adult;
Aged;
Arthritis, Rheumatoid/*immunology;
Chromium Radioisotopes/diagnostic use;
Comparative Study;
Cytotoxicity Tests, Immunologic/methods;
*Cytotoxicity, Immunologic;
Female;
Human;
In Vitro;
Killer Cells, Natural/*immunology;
Male;
Middle Age;
Support, Non-U.S. Gov't;
Synovial Fluid/immunology
- From:Yonsei Medical Journal
1988;29(2):160-165
- CountryRepublic of Korea
- Language:English
-
Abstract:
The natural killer(NK) cell activity of mononuclear cells (MNC) from peripheral blood (PB) and synovial fluid (SF) of 40 rheumatoid arthritis(RA) patients was investigated by employing 51-chromium-(51Cr) release microcytotoxicity and single cell cytotoxicity assays against K562 target cells. It has been revealed that SF-MNC from RA patients showed a significantly lower NK activity than PB-MNC from the same patients and this might be due to an impaired target binding capacity of the effector cells and not due to a deficiency of active NK cells.
