Change in Plasma Vascular Endothelial Growth Factor after Gamma Knife Radiosurgery for Meningioma: A Preliminary Study.
10.3340/jkns.2015.57.2.77
- Author:
Seong Hyun PARK
1
;
Jeong Hyun HWANG
;
Sung Kyoo HWANG
Author Information
1. Department of Neurosurgery, Kyungpook National University Hospital, Daegu, Korea. nsdoctor@naver.com
- Publication Type:Original Article
- Keywords:
Gamma Knife radiosurgery;
Meningioma;
Stereotactic radiosurgery;
Vascular endothelial growth factor
- MeSH:
Edema;
Enzyme-Linked Immunosorbent Assay;
Healthy Volunteers;
Humans;
Meningioma*;
Plasma*;
Radiosurgery*;
Vascular Endothelial Growth Factor A*
- From:Journal of Korean Neurosurgical Society
2015;57(2):77-81
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The purpose of this study was to investigate changes in the plasma level of vascular endothelial growth factor (VEGF) after Gamma Knife radiosurgery (GKRS) for the treatment of meningioma. METHODS: Fourteen patients with meningiomas had peripheral venous blood collected at the time of GKRS and at 1 week, 1 month, 3 month and 6 month visits. Plasma VEGF levels were measured using commercially available enzyme-linked immunosorbent assay. For controls, peripheral blood samples were obtained from 20 healthy volunteers. RESULTS: The mean plasma VEGF level (29.6 pg/mL) in patients with meningiomas before GKRS was significantly lower than that of the control group (62.4 pg/mL, p=0.019). At 1 week after GKRS, the mean plasma VEGF levels decreased to 23.4 pg/mL, and dropped to 13.9 pg/mL at 1 month, 14.8 pg/mL at 3 months, then increased to 27.7 pg/mL at 6 months. Two patients (14.3%) with peritumoral edema (PTE) showed a level of VEGF 6 months after GKRS higher than their preradiosurgical level. There was no significant association found in an analysis of correlation between PTE and tumor size, marginal dose, age, and sex. CONCLUSION: Our study is first in demonstrating changes of plasma VEGF after stereotactic radiosurgery (SRS) for meningioma. This study may provide a stimulus for more work related to whether measurement of plasma level has a correlation with tumor response after SRS for meningioma.
