Correlations between Coronary Plaque Tissue Composition Assessed by Virtual Histology and Blood Levels of Biomarkers for Coronary Artery Disease.
10.3349/ymj.2012.53.3.508
- Author:
Young Guk KO
1
;
Van Cuong LE
;
Bo Hyun KIM
;
Dong Ho SHIN
;
Jung Sun KIM
;
Byeong Keuk KIM
;
Donghoon CHOI
;
Yangsoo JANG
;
Myeong Ki HONG
Author Information
1. Division of Cardiology, Severance Cardiovascular Hospital & Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea. mkhong61@yuhs.ac
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Atherosclerosis;
coronary artery disease;
inflammation;
intravascular ultrasound
- MeSH:
Aged;
Angina Pectoris/blood;
Angina, Stable/blood;
Angina, Unstable/blood;
Angioplasty, Balloon, Coronary;
Biological Markers/blood;
C-Reactive Protein/metabolism;
CD40 Ligand/blood;
Coronary Artery Disease/*blood/*metabolism/ultrasonography;
Female;
Humans;
Male;
Matrix Metalloproteinase 9/blood;
Middle Aged;
Neopterin/blood;
Plaque, Atherosclerotic/*blood/*metabolism/ultrasonography;
Ultrasonography, Interventional
- From:Yonsei Medical Journal
2012;53(3):508-516
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We investigated correlations of coronary plaque composition determined by virtual histology (VH) intravascular ultrasound (IVUS) and blood levels of biomarkers that represent the vulnerability of coronary plaques. MATERIALS AND METHODS: Pre- and postprocedural blood levels of high sensitivity C-reactive protein, soluble CD40 ligand (sCD40L), matrix metalloproteinase-9, and neopterin were measured in 70 patients with stable angina (SA) or unstable angina (UA) who were undergoing percutaneous coronary intervention (PCI) for single lesions. We evaluated the data for correlations between these biomarkers and necrotic core contents in PCI target lesions analyzed by VH. RESULTS: Clinical characteristics, IVUS, VH, and biomarker blood levels were not different between the SA and the UA group except for more frequent previous statin use (52.3% vs. 23.1%, p=0.017) and lower remodeling index in the SA group (0.98+/-0.09 vs. 1.10+/-0.070, p<0.001). Among the biomarkers evaluated, only pre-PCI neopterin level showed a weakly significant correlation with the absolute volume of the necrotic core (r=0.320, p=0.008). Pre- and post-PCI blood levels of sCD40L (r=0.220, p=0.072; r=0.231, p=0.062) and post-PCI blood level of neopterin (r=0.238, p=0.051) showed trends toward weakly positive correlations with the absolute volume of necrotic core. CONCLUSION: We found a weakly positive correlation between the pre-PCI neopterin level and necrotic core volume in the PCI-target lesion. The clinical implications of our findings need to be investigated in further studies.
