Health Related Quality of Life in Common Variable Immunodeficiency.
10.3349/ymj.2012.53.3.603
- Author:
Isabella QUINTI
1
;
Cristina DI PIETRO
;
Helene MARTINI
;
Anna Maria PESCE
;
Francesca LOMBARDI
;
Maddalena BAUMGHARTNER
;
Stefania COLANTUONO
;
Cinzia MILITO
;
Stefano TABOLLI
Author Information
1. Department of Molecular Medicine, Sapienza University of Rome and Fondazione Eleonora Lorillard Spencer Cenci, Rome, Italy.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Common Variable Immunodeficiency;
Health Related Quality of Life;
SF-36;
General Health Questionnaire-12;
GHQ-12
- MeSH:
Chronic Disease;
Common Variable Immunodeficiency/*physiopathology;
Female;
Health Status;
Humans;
Male;
*Quality of Life;
Questionnaires
- From:Yonsei Medical Journal
2012;53(3):603-610
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To quantify the health related quality of life in primary immunodeficiency patients. MATERIALS AND METHODS: We used generic health status and general psychological health questionnaires to determine the range of issues that needed to be considered in examining the burden of common variable immunodeficiency (CVID). RESULTS: The health status of patients with CVID was lower than that observed in normal subjects. Overall, Role-Physical and General Health scales correlated with a poorer clinical status. Surprisingly, the duration of disease did not influence health status. Being female, older, General Health Questionnaire-positive and alexithymic proved to be major risk factors associated with a poor health status. Patients with chronic lung disease and chronic diarrhea had the lowest values on the Medical Outcome Study, Short Form SF-36 (SF-36) scales. Disease severity perception was associated with the General Health Questionnaire and alexithymia status. Limitations in daily activities as a result of lower physical health were the major problems facing common variable immunodeficiency patients. CONCLUSION: Our data underlined the importance of conducting a periodical health related quality of life assessment on patients with primary antibody deficiencies and, moreover, stressed the necessity of providing psychological support to at risk patients.
