Use of Omega-3 Polyunsaturated Fatty Acids to Treat Inspissated Bile Syndrome: A Case Report.
10.5223/pghn.2016.19.4.286
- Author:
Woo Young JUN
1
;
Min Jeng CHO
;
Hye Seung HAN
;
Sun Hwan BAE
Author Information
1. Department of Pediatrics, Konkuk University Medical Center, Seoul, Korea. baedori@hanafos.com
- Publication Type:Case Report
- Keywords:
Inspissated bile syndrome;
Cholestasis;
Omega-3 fatty acids
- MeSH:
Bile Ducts, Extrahepatic;
Bile*;
Biliary Atresia;
Biopsy;
Cholangiography;
Cholangiopancreatography, Magnetic Resonance;
Cholestasis;
Common Bile Duct;
Diagnosis;
Diagnostic Tests, Routine;
Fatty Acids, Omega-3;
Fatty Acids, Unsaturated*;
Female;
Humans;
Infant;
Jaundice;
Liver;
Sewage;
Ultrasonography
- From:Pediatric Gastroenterology, Hepatology & Nutrition
2016;19(4):286-290
- CountryRepublic of Korea
- Language:English
-
Abstract:
Inspissated bile syndrome (IBS) is a rare condition in which thick intraluminal bile, including bile plugs, sludge, or stones, blocks the extrahepatic bile ducts in an infant. A 5-week-old female infant was admitted for evaluation of jaundice and acholic stool. Diagnostic tests, including ultrasound sonography, magnetic resonance cholangiopancreatography, and a hepatobiliary scan, were not conclusive. Although the diagnosis was unclear, the clinical and laboratory findings improved gradually on administration of urodeoxycholic acid and lipid emulsion containing omega-3 polyunsaturated fatty acids (PUFAs) for 3 weeks. However, a liver biopsy was suggestive of biliary atresia. This finding forced us to perform intraoperative cholangiography, which revealed a patent common bile duct with impacted thick bile. We performed normal saline irrigation and the symptom was improved, the final diagnosis was IBS. Thus, we herein report that IBS can be treated with omega-3 PUFAs as an alternative to surgical intervention.
