Human Leukocyte Antigen-DRB1 Associations in Korean Juvenile Rheumatoid Arthritis.
10.4078/jrd.2014.21.4.182
- Author:
Chan Jae LEE
1
;
Tae Young SOHN
;
Dae Hyoung LEE
;
Hae Ran LEE
;
Miyoung KIM
;
Kwang Nam KIM
Author Information
1. Department of Pediatric, Hallym University Sacred Heart Hospital, Anyang, Korea. kwangnamkim@naver.com
- Publication Type:Original Article
- Keywords:
Juvenile rheumatoid arthritis;
Human leukocyte antigen;
HLA-DRB1
- MeSH:
Adult;
Alleles;
Arthritis, Juvenile*;
Child;
HLA-DRB1 Chains;
Humans;
Leukocytes*;
Phenotype
- From:Journal of Rheumatic Diseases
2014;21(4):182-186
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of this study is to investigate the association of different subgroups of juvenile rheumatoid arthritis (JRA) with human leukocyte antigen (HLA) class II DR alleles. METHODS: One hundred and nineteen Korean juvenile rheumatoid arthritis patients were classified as HLA-DRB1 allele. To assess the frequency, phenotype frequencies of all JRA cases and each subtypes were compared to those of 485 adult controls. RESULTS: HLA-DRB1*01 was associated with increased risk of JRA. Furthermore, DRB1*01 was associated with polyarticular JRA and pauciarticular JRA. The frequencies of DRB1*14 and DRB1*15 were higher in systemic JRA patients than the controls. CONCLUSION: The data of this study on Korean children with JRA suggests that HLA-DRB1*01 was associated with the susceptibility of JRA. The study should be extended to include larger numbers of patients.
