Serum level changes of long chain-polyunsaturated fatty acids in patients undergoing periodontal therapy combined with one year of omega-3 supplementation: a pilot randomized clinical trial.
10.5051/jpis.2014.44.4.169
- Author:
Gisele Lago MARTINEZ
1
;
Josely Correa KOURY
;
Marcela Anjos MARTINS
;
Fernanda NOGUEIRA
;
Ricardo Guimaraes FISCHER
;
Anders GUSTAFSSON
;
Carlos Marcelo S FIGUEREDO
Author Information
1. Institute of Odontology, Department of Periodontology, Rio de Janeiro State University, Rio de Janeiro, Brazil. cmfigueredo@hotmail.com
- Publication Type:Clinical Trial ; Original Article ; Randomized Controlled Trial
- Keywords:
Arachidonic acid;
Omega-3 fatty acid;
Periodontitis
- MeSH:
Arachidonic Acid;
Capsules;
Dietary Supplements;
Eicosapentaenoic Acid;
Fatty Acids*;
Follow-Up Studies;
Humans;
Periodontitis;
Root Planing
- From:Journal of Periodontal & Implant Science
2014;44(4):169-177
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We aimed to investigate the impact of nonsurgical periodontal treatment combined with one-year dietary supplementation with omega (omega)-3 on the serum levels of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and arachidonic acid (AA). METHODS: Fifteen patients with chronic generalized periodontitis were treated with scaling and root planing. The test group consisted of seven patients (43.1+/-6.0 years) supplemented with omega-3, consisting of EPA plus DHA, three capsules, each of 300 mg of omega-3 (180-mg EPA/120-mg DHA), for 12 months. The control group was composed of eight patients (46.1+/-11.6 years) that took a placebo capsule for 12 months. The periodontal examination and the serum levels of DPA, EPA, DHA, and AA were performed at baseline (T0), and 4 (T1), and 12 (T2) months after therapy. RESULTS: In the test group, AA and DPA levels had been reduced significantly at T1 (P<0.05). AA and EPA levels had been increased significantly at T2 (P<0.05). The DeltaEPA was significantly higher in the test compared to the placebo group at T2-T0 (P=0.02). The AA/EPA had decreased significantly at T1 and T2 relative to baseline (P<0.05). CONCLUSIONS: Nonsurgical periodontal treatment combined with omega-3 supplementation significantly increased the EPA levels and decreased the AA/EPA ratio in serum after one year follow-up. However, no effect on the clinical outcome of periodontal therapy was observed.
