A Case of Acute Q Fever with Severe Acute Cholestatic Hepatitis.

Author: Hyun Cheul CHOI ¹ ; Sang Hyub LEE ; Junghee KIM ; Sung Han KIM ; Jin Hyeok HWANG ; Jin Wook KIM ; Sook Hyang JEONG ; Haeryoung KIM
Author Information

1. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. gidoctor@korea.com, gidoctor@snubh.org
Publication Type:Case Report
Keywords: Acute Q fever; Fibrin-ring granuloma; Severe cholestatic hepatitis
MeSH: Ascites; Biopsy; DNA; Fever; Granuloma; Hepatitis; Humans; Immunoglobulin G; Immunoglobulin M; Jaundice; Liver; Male; Middle Aged; Polymerase Chain Reaction; Psychomotor Agitation; Q Fever
From:Gut and Liver 2009;3(2):141-144
CountryRepublic of Korea
Language:English
Abstract: Minimal hepatic dysfunction can be common in acute Q fever, but severe acute cholestatic hepatitis is rarely reported. We report on a 55-year-old male with acute Q fever and severe acute cholestatic hepatitis. He complained of fever, jaundice, ascites, and restlessness on admission. A liver biopsy revealed the presence of compact fibrin-ring granulomas. Serologic titers for C. burnetii IgM and IgG were 2048:1 and 1024:1, respectively. C. burnetii DNA was detected by a nested polymerase chain reaction on the liver tissue.