Comparison of etomidate and propofol on intubating conditions and the onset time associated with cisatracurium administration.
10.4097/kjae.2015.68.2.136
- Author:
Young Kwon KO
1
;
Yoon Hee KIM
;
Sang Il PARK
;
Woo Suk CHUNG
;
Chan NOH
;
Jung Un LEE
Author Information
1. Department of Anesthesiology and Pain Medicine, Chungnam National University College of Medicine, Daejeon, Korea. yhkim0404@cnu.ac.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Cisatracurium;
Etomidate;
Intratracheal intubation;
Neuromuscular blockade;
Propofol
- MeSH:
Anesthesia, General;
Anesthetics;
Blood Pressure;
Etomidate*;
Female;
Heart Rate;
Humans;
Intubation, Intratracheal;
Neuromuscular Blockade;
Propofol*
- From:Korean Journal of Anesthesiology
2015;68(2):136-140
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study compared intubating conditions and the onset time associated with administration of cisatracurium, a nondepolarizing neuromuscular blocker with a relatively slow onset, according to prior injection of one of two intravenous anesthetic agents: propofol or etomidate. METHODS: Forty-six female patients, undergoing general anesthesia and endotracheal intubation for elective surgery, were randomized to two groups; group P were administered propofol (2 mg/kg) prior to cisatracurium (0.2 mg/kg); group E were administered etomidate (0.3 mg/kg) prior to cisatracurium (0.2 mg/kg). We measured intubating conditions and the onset time according to the types of intravenous anesthetic administered. Measurements of heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were taken immediately prior to induction; immediately and 1 min after IV anesthetic administration; and immediately and 1, 2, 3, 4, 5, 7, and 15 min after endotracheal intubation. RESULTS: Intubating conditions were superior in group E compared with group P (P = 0.009). The average onset time of cisatracurium was more rapid in group E (155.74 +/- 32.92 s vs. 185.26 +/- 38.57 s in group P; P = 0.008). There were no group differences in SBP, DBP, and HR following intravenous anesthetic drug injection and endotracheal intubation. However, SBP and DBP were substantially higher in group E after endotracheal intubation. CONCLUSIONS: Etomidate improves intubating conditions and provide a more rapid onset time of cisatracurium during anesthetic induction compared to propofol.
