A Case of Neuroleptic Malignant Syndrome (NMS) with Myoglobulinemic Acute Renal Failure and Lithium Intoxication due to Lithium-olanzapine Combination.
- Author:
Won Taek OH
1
;
Chi Hoon MAENG
;
Mi Na PARK
;
Sun Young CHOI
;
Kyung Hwan JEONG
;
Ju Young MOON
;
Tae Won LEE
;
Cheon Gyu IHM
;
Sang Ho LEE
Author Information
1. Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea. rulale@dreamwiz.com
- Publication Type:Case Report
- Keywords:
Neuroleptic malignant syndrome (NMS);
Acute renal failure;
Lithium intoxication
- MeSH:
Female;
Humans;
Neuroleptic Malignant Syndrome
- From:Korean Journal of Nephrology
2006;25(5):835-839
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a patient developed neuroleptic malignant syndrome (NMS) with myoglobulinemic acute renal failure and lithium intoxication due to lithium-olanzapine combination, who was successfully treated by hemodiafiltration. A 34-year-old woman with a 14-year history of bipolar disorder had been treated with lithium-olanzapine during last four days. She was admitted to our hospital for muscular rigidity, hyperthermia and altered consciousness. On admission, rhabdomyolsis was demonstratd by biochemical methods and serum level of lithium was 3.78 mEq/L which was far above toxic level. After the diagnosis of NMS with acute renal failure and lithium intoxication, olanzapine and lithium were discontinued and conservative measures and continuous venovenous hemodiafiltration were instituted. She recovered without any neurologic sequelae.
