A Case of Diffuse Large B-cell Lymphoma in a Kidney Transplant Recipient.
- Author:
Seung Woon BYUN
1
;
Hye Won PARK
;
Ju Hyung SONG
;
Ji Seon OH
;
Eun Hee KIM
;
Joo Ryung HUH
;
Cheolwon SUH
;
Su Kil PARK
Author Information
1. Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. skpark@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Posttransplant lymphoproliferative disorders (PTLD);
EBV (Epstein-Barr virus);
Immunosuppression;
Kidney transplantation
- MeSH:
Male;
Humans
- From:Korean Journal of Nephrology
2006;25(5):871-876
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Posttransplant lymphoproliferative disorders (PTLD) is an infrequent but serious complication of transplantation. Previous studies have suggested the terms of reference, "early PTLD" (referring to PTLD that occurs within 1 year of transplantation) and "late PTLD" (PTLD that occurs after 1 year). Early PTLD generally involves a single organ or nodal region and often responds favorably to a decrease in immunosuppression. Late PTLD tends to be disseminated, responds less frequently to a decrease in immunosuppression, and has a dismal prognosis. We encountered a diffuse large B-cell lymphoma in a 44-year-old man who underwent kidney transplantation over 10 years ago, in 1995. In situ hybridization for Epstein-Barr virus showed positive results in tumor cell. With decreased immunosuppressants and chemotheraphy, he is currently in complete remission.
