Obstetrical Outcomes of Increased Nucleated RBC in Maternal Blood during Early Pregnancy.
- Author:
Geun A SONG
1
;
Sang Hoon LEE
;
Dong Hoon BAEK
;
Goo Hwa JE
;
Jin Yeong HAN
Author Information
1. Department of Obstetrics and Gynecology, Clinical Pathology, College of Medicine, Dong-A University.
- Publication Type:Original Article
- Keywords:
Nucleated RBC;
High risk pregnancy;
Screening test
- MeSH:
Anemia;
Antibodies;
Birth Weight;
Female;
Fetal Development;
Flow Cytometry;
Gestational Age;
Glycophorin;
Humans;
Hypertension, Pregnancy-Induced;
Mass Screening;
Obstetric Labor, Premature;
Pre-Eclampsia;
Pregnancy Trimester, Second;
Pregnancy*;
Pregnancy, High-Risk;
Pregnant Women;
Risk Factors
- From:Korean Journal of Obstetrics and Gynecology
2001;44(10):1817-1822
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: During early pregnancy, CD71 and glycophorin A positive cells in peripheral blood of pregnant women were studied, to assess the relationship between increased numbers of nucleated RBC (NRBC) in maternal blood and pregnant outcomes. METHODS: Peripheral venous blood samples were obtained from 47 primigravidas of 14~16 weeks gestation. Triple screening tests were routinely performed. Blood samples were incubated with monoclonal anti-CD71 and monoclonal anti-glycophorin antibodies, and analyzed by flow cytometry using FACSort (Becton Dickinson, USA) for checking the NRBC count. RESULTS: A total of 47 pregnant women were enrolled at 14-16 weeks gestation; one pregnancy had anemia and was excluded from the test, the outcome was unknown for 2 other pregnancies, and twelve pregnancies had 1-4% of NRBC in the maternal blood. In the remaining 32 pregnant women, grouped according to their percentage of NRBC, the group with more than 4% of NRBC was termed the study group, and less than 1% of NRBC was termed the control group.The results were as follows: 1) The study group showed lower fetal birth weight than the control group, which was statistically negatively significant (y=-62.219x + 3,401.6, R2=0.2146, p<0.05).2) There was no significant correlation between the percentage of NRBC of maternal blood and maternal serum AFP level in the study and the control groups (y=-0.0206x + 1.2763, R2 =0.0096, p>0.05).3) There were two complications in the study group: one was a preterm delivery at 35 weeks of gestational age with birth weight of 2,300 gm and the other was a case of pregnancy-induced hypertension. CONCLUSION: It can be concluded that increased NRBC count in maternal blood during the early second trimester has a significant correlation with fetal birth weight but can't predict high risk pregnancies such as preeclampsia, preterm labor or intrauterine fetal growth restriction.In order to obtain a higher predictive value, further studies with more participants and with high risk pregnancies of known risk factors are needed.
