An Association Study of D9S158 Polymorphism(VNTR Marker Linked to the NMDA Receptor Gene) with korean Schizophrenics.
- Author:
Byung Hwan YANG
1
;
Kang Kyu PARK
;
Eun Kee CHUNG
;
Jin Hee HAN
;
Jong Won KIM
;
Ihn Geun CHOI
;
Young Ho LEE
;
Gil Sook KIM
;
Young Gyu CHAI
Author Information
1. Department of Neuropsychiatry, College of Medicine and the Mental Health Research Institute, Hanyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Association;
Chromosome 9;
Polymorphism;
Alleles
- MeSH:
Alleles;
Chromosomes, Human, Pair 9;
Humans;
N-Methylaspartate*;
Phenotype;
Polymerase Chain Reaction;
Schizophrenia
- From:Journal of Korean Neuropsychiatric Association
1998;37(5):974-982
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
An association study with Korean schizophrenic patients(N=75) and normal controls(N=87) was performed to find the relationship between D9S158 polymorphism and schizophrenia using polymerase chain reaction. Eight different alleles of a dinucleotide polymorphism on D9S158 locus were observed in both group. When we compared the frequencies of alleles between schizophrenics and normal controls, there was no significant difference between two groups. To increase homogeneity of schizophrenic group, we divided schizophrenic group by clinical phenotypes such as family history, negative and positive symptoms(PANSS), soft neurologic signs(NES-K) and DSM-lV diagnostic subtypes. Then we compared the frequencies of alleles among subgroups of clinical phenotypes, and there were no significant differences between subgroups(p>.05). Although our findings fail to provide an evidence of association between schizophrenia and D9S158 locus, further investigation of other loci that are linked to NMDA receptor gene may be needed in genetically homogeneous subgroups of schizophrenia.
