Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease.
- Author:
Se Young NA
1
;
Mira CHOI
;
Min Ji KIM
;
Jong Hee LEE
;
Soyun CHO
Author Information
- Publication Type:Case Report
- Keywords: Cutis laxa; Elastosis perforans serpiginosa; Penicillamine; Wilson's disease
- MeSH: Adult; Anetoderma; Cutis Laxa; Cystinuria; Elastic Tissue; Hepatolenticular Degeneration; Humans; Korea; Penicillamine; Skin Diseases
- From:Annals of Dermatology 2010;22(4):468-471
- CountryRepublic of Korea
- Language:English
- Abstract: Elastosis perforans serpiginosa (EPS) is a rare reactive perforating dermatosis that is characterized by the transepidermal elimination of abnormal elastic fibers. Penicillamine, which is one of the clear triggers for EPS, is a heavy metal chelator that is primarily used for disorders such as cystinuria and Wilson's disease. It may cause alterations in the dermal elastic tissue such as pseudo-pseudoxanthoma elasticum, acquired cutis laxa, EPS and anetoderma. Herein we present a case of cutis laxa and EPS in a 34-year-old man who was previously on a long-term, high-dose of penicillamine for Wilson's disease. The combination of EPS and cutis laxa induced by penicillamine has rarely been reported and we report the first such case in Korea.
