Effect of Environmental Factors on Depressive-like Behavior and Memory Function in Adolescent Rats.
10.7586/jkbns.2017.19.4.276
- Author:
Min Kyung SONG
1
;
Jae Min LEE
;
Yoon Ju KIM
;
Joo Hee LEE
;
Youn Jung KIM
Author Information
1. Department of Nursing, Graduate School, Kyung Hee University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Adolescent;
Social environment;
Depression;
Cognition
- MeSH:
Adolescent*;
Animals;
Behavior Rating Scale;
Cognition;
Depression;
Humans;
Memory*;
Rats*;
Rats, Wistar;
Social Environment;
Water
- From:Journal of Korean Biological Nursing Science
2017;19(4):276-283
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of this study was to identify the effects of environmental factors on depressive-like behavior and memory function during adolescence. We performed behavior tests in adolescent rats exposed to environmental enrichment, handling, and social deprivation for eight weeks. METHODS: Wistar rats were randomly assigned to control, environmental enrichment, handling, and social deprivation groups at the age of four weeks. RESULTS: In the forced swim test, the immobility time in the environmental enrichment group was decreased than that in the control group (p=.038), while the immobility time in the social deprivation group was increased than that in the control group (p=.035), the environmental enrichment group (p<.001), and the handling group (p=.001). In the Morris water maze test, the social deprivation group had an increased latency time than the control group (p=.013) and the environmental enrichment group (p=.001). In the passive avoidance test, the environmental enrichment group had an increased latency time than the control group (p=.005). However, the social deprivation group had reduced latency time than the socially housed groups (control: p=.030; environmental enrichment: p<.001; handling: p<.001). CONCLUSION: These findings suggest that environmental factors play an important role in emotion and memory function during adolescence.
